Protein Details: Amiloride-sensitive sodium channel subunit delta
Protein ID
ICDB_Pro_0219
Protein Name
Amiloride-sensitive sodium channel subunit delta
Gene Name
SCNN1D; DNACH
Organism
Pan troglodytes (Chimpanzee)
Length
638 amino acids
AlphaFoldDB
AF-O46547-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney; colon; lung and sweat glands. Also plays a role in taste perception.
Sequence
MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSQGRAALSAPVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWCHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGAEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPRQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPTPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
RefSeq
NP_001009072.1